Part 2 | Bridging the Gap: A Panel Discussion on Human and Animal Health

Moderator

Christine Green, MD, Co-director of Education, Invisible International

Panelists

Edward Breitschwerdt, DVM, Melanie S. Steele Professor of Medicine and Infectious Diseases, Comparative Medicine Institute, NCSU College of Veterinary Medicine

Elizabeth Lee-Lewandrowski, PhD, MPH, Massachusetts General Hospital, Harvard Medical School, Research Director of Invisible International

Charlotte Mao, MD, MPH, Curriculum Director, Invisible International

Stephen Phillips, MD

Description

In the “Bridging the Gap: A Panel Discussion on Human and Animal Health” CME series, physicians will learn about the vital connection between human and animal health in managing chronic infectious diseases. Led by Dr. Chris Green and featuring experts from diverse fields, the discussion focuses on chronic manifestations of vector-borne diseases like Lyme disease, the One Health approach, and advancements in diagnostic testing. The panelists, including experts in pathology, veterinary medicine, and infectious diseases, emphasize integrated treatment approaches and the significance of comprehensive patient histories. They also discuss the importance of collaborative research and data sharing in understanding disease prevalence and developing effective treatment strategies. This course aims to enhance physicians’ understanding of the complexities of vector-borne diseases and the importance of a collaborative, cross-disciplinary approach in healthcare.

Learning objectives

1. Identify and describe the key characteristics and challenges of diagnosing and managing chronic manifestations of vector-borne diseases, such as Lyme disease and bartonellosis.
2. Recognize the importance of a comprehensive patient history in the diagnosis and treatment of vector-borne diseases, and integrate this approach into clinical practice.
3. Discuss the clinical presentations and complexities of Lyme disease as a model for understanding other vector-borne diseases, and apply this knowledge in clinical settings.

CME Credit Pending. Application for CME credit has been filed with the American Academy of Family Physicians. Determination of credit is pending.

Articles for Further Study:

Concurrent infection of the Central Nervous systemby Borrelia burgdorferi and Bartonella hensellae: Evidence for a novel Tick-bornedisease complex.

E. Eskow, R.S. Rao, and E. Modechai.

---

Cat-scratch disease. Subtle vertebral bone marrow abnormalities demonstrated by MR imaging and radionuclide bone scan.

Wilson JD1, Castillo M.

---

Fever, bone pain and erectile dysfunction. Where is the cat?

Quentin Trefois, Jean-Christophe Marot,Halil Yildiz, and Gregoire Wieers

---

Abscess-forming lymphadenopathy and osteomyelitis in children with Bartonella henselae infection.

Ridder-Schröter R, Marx A, Beer M, Tappe D, Kreth HW, Girschick HJ.

---

Role of magnetic resonance imaging and scintigraphy in the diagnosis and follow-up of osteomyelitis in cat-scratch disease.

Rozmanic V, Banac S, Miletic D, Manestar K, Kamber S, Paparic S.

---

Cat-scratch disease presenting as multifocal osteomyelitis with thoracic abscess.

Modi SP, Eppes SC, Klein JD.

---

Disseminated Bartonella henselae (cat-scratch disease): appearance of multifocal osteomyelitis with MR imaging.

Ratner LM1, Kesack A, McCauley TR, Disler DG.

---

An atypical case of Bartonella henselae osteomyelitis and hepatic disease

Mathews DM, Vance KM, McMahon PM, Boston C, Bolton MT.

---

Multifocal bone marrow involvement in cat-scratch disease.

Hipp SJ1, O’Shields A, Fordham LA, Blatt J, Hamrick HJ, Henderson FW.

---

Musculoskeletal manifestations of cat scratch disease.

Maman E1, Bickels J, Ephros M, Paran D, Comaneshter D, Metzkor-Cotter E, Avidor B, Varon-Graidy M, Wientroub S, Giladi M.

---

Bone infection in cat-scratch disease: a review of the literature.

Hajjaji Hocquelous, Kerdraon Bret

---

Picture of the month–quiz case

Eric J. Haas, Linda Ernst

---

Cat scratch disease presenting as multifocal osteitis

Gallemore Worley

---

Case Report: Possible Vertical Transmission of Bartonella bacilliformis in Peru.

Tuya Ximena L, Raffo Escalante-Kanashiro, Carmen Tinco, Maria J. Pons, Verónica Petrozzi, Joaquim Ruiz, and Juana del Valle • January 7, 2015

---

Bartonella spp. – a chance to establish One Health concepts in veterinary and human medicine.

Regier Yvonne, Fiona O´Rourke, and Volkhard A. J. Kempf • May 10, 2016

---

Minireview, Recommendations for the Treatment of Human infections caused by Bartonella species.

Rolain, JM, P Brouqui, ME Koehler, C Maguina, MJ Dolan, and D raout • June 2006

---

Bartonella spp. Bacteremia and Rheumatic Symptoms in Patients from Lyme Disease–endemic Region

Maggi Ricardo G., B. Robert Mozayeni, Elizabeth L. Pultorak, Barbara C. Hegarty, Julie M. Bradley,Maria Correa, and Edward B. Breitschwerdt • May 2012

---

A prospective study of canine infective endocarditis in northern California (1999– 2001): emergence of Bartonella as a prevalent etiologic agent

MacDonald K.A., Chomel B.B., Kittleson M.D., Kasten R.W., Thomas W.P., Pesavento P • June 28, 2008

---

Co-infection with Anaplasma platys, Bartonella henselae and Candidatus Mycoplasma haematoparvum in a veterinarian

Maggi, RG and PE Mascarelli, LN Havenga, V Naidoo and EB Breitschwerdt. • April 15, 2013

---

Coinfection with Multiple Tick-Borne Pathogens in a Walker Hound Kennel in North Carolina.

Kordick, S. K EB. Breitschwerdt, BC Hegarty,KL. Southwick, CM Colitz, S. I. Hancock, JM. Bradley, LR Rumbough, JT. Mcpherson, & JN Maccormack • August 1999

---

Intruders below the radar: molecular pathogenesis of Bartonella ssp.

Harms, Alexander and Christoph Dehio. • January 2012

---

Bartonella Infection in Animals: Carriership, Reservoir Potential, Pathogenicity, and Zoonotic Potential for Human Infection.

Breitschwerdt Edward B. AND Dorsey K Kordick • July 2000

---

Molecular and Cellular Basis of Bartonella Pathogenesis.

Dehio, Christoph,. • October 13, 2004

---

Bartonella sp. Bacteremia in Patients with Neurological and Neurocognitive Dysfunction

Breitschwerdt EB, R. G. Maggi, W. L. Nicholson,2 N. A. Cherry, and C. W. Woods. • July 10, 2008

---

Hallucinations, Sensory Neuropathy, and Peripheral Visual Deficits ina Young Woman Infected with Bartonella koehlerae.

Breitschwerdt Edward B., P. Mascarelli, LA. Schweickert, RG. Maggi, BC. Hegarty, JM. Bradley, and C Woods. • June 28, 2011

---

Factors associated with the rapid emergence of zoonotic Bartonella infections.

Boulouis Henri-Jean, Chao-chin Chang, Jennifer B. Henn, Rickie W. Kasten, Bruno B. Chomel. • December 17, 2004