Long Lyme/Co-Infections and Long COVID | What do they have in common?

0.5 CME. This course provides a summary of similarities between clinical and biological manifestations of chronic Lyme disease and long COVID. It presents results of a published clinical trial on low dose naltrexone as an agent in long COVID.


John Lambert, MD
Full Clinical Professor, University College Dublin School of Medicine
Consultant in Infectious Diseases and Genitourinary Medicine, Mater Misericordiae University Hospital


This CME is intended to help clinicians draw a parallel between long COVID and long Lyme disease by understanding the clinical manifestations and potential treatment options.  Content for this free course was compiled by a team of clinicians, and researchers potentially speeding up treatment decisions and saving lives.

Learning objectives

  1. Describe what we can learn from chronic Lyme and apply to long COVID
  2. Understand the potential role of chronic infection, autoimmunity and inflammation as it relates to patient symptoms
  3. Increase awareness of the options for treatment of long COVID

This session, Long Lyme/Co-Infections and Long COVID | What do they have in common?, is approved for 0.5 enduring AAFP Prescribed credits.

AAFP Prescribed credit is accepted by the American Medical Association as equivalent to AMA PRA Category 1 credit(s)™ toward the AMA Physician’s Recognition Award. When applying for the AMA PRA, Prescribed credit earned must be reported as Prescribed, not as Category 1.

The AAFP has reviewed One Health Medical Education for a Changing Climate and deemed it acceptable for AAFP credit. Term of approval is from 01/02/2024 to 01/01/2025. Physicians should claim only the credit commensurate with the extent of their participation in the activity.


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O’Kelly B, Vidal L, Avramovic G, Broughan J, Connolly SP, Cotter AG, Cullen W, Glaspy S, McHugh T, Woo J, Lambert JS. Assessing the impact of COVID-19 at 1-year using the SF-12 questionnaire: Data from the Anticipate longitudinal cohort study. Int J Infect Dis. 2022 May;118:236-243. doi: 10.1016/j.ijid.2022.03.013. Epub 2022 Mar 14. PMID: 35301101; PMCID: PMC8920113.

Broughan J, McCombe G, O’Kelly B et al. Mental health and alcohol use among patients attending a post-COVID-19 follow-up clinic: a cohort study [version 1; peer review: 1 approved]. HRB Open Res 2022, 5:16 (https://doi.org/10.12688/hrbopenres.13503.1)

Verger A, Kas A, Dudouet P, Goehringer F, Salmon-Ceron D, Guedj E. Visual interpretation of brain hypometabolism related to neurological long COVID: a French multicentric experience. Eur J Nucl Med Mol Imaging. 2022 Jul;49(9):3197-3202. doi: 10.1007/s00259-022-05753-5. Epub 2022 Mar 23. PMID: 35320385; PMCID: PMC8941296.

O’Kelly B, Vidal L, McHugh T, Woo J, Avramovic G, Lambert JS. Safety and efficacy of low dose naltrexone in a long covid cohort; an interventional pre-post study. Brain Behav Immun Health. 2022 Oct;24:100485. doi: 10.1016/j.bbih.2022.100485. Epub 2022 Jul 3. PMID: 35814187; PMCID: PMC9250701.

Pedro Gutiérrez-Castrellón, Tania Gandara-Martí, Ana T. Abreu Y Abreu, Cesar D. Nieto-Rufino, Eduardo López-Orduña, Irma Jiménez-Escobar, Carlos Jiménez-Gutiérrez, Gabriel López-Velazquez & Jordi Espadaler-Mazo (2022) Probiotic improves symptomatic and viral clearance in Covid19 outpatients: a randomized, quadruple-blinded, placebo-controlled trial, Gut Microbes, 14:1, 2018899, DOI: 10.1080/19490976.2021.2018899

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Course Includes

  • 1 Lesson
  • 2 Quizzes
  • Course Certificate