Part 2 | Diagnostic, treatment & rehabilitation strategies for patients with CNS Lyme disease

CME Pending. This course provides a summary of clinical and radiological presentations of CNS Lyme Disease.

Nev Zubcevik, DO
Chief Medical Officer
Invisible International


This course is intended to help clinicians decide when to order radiologic tests for CNS Lyme disease, based on symptoms and clinical presentation. This concise, data-driven overview will help clinicians quickly decide which radiologic tests to order after a tick-bite, potentially speeding up treatment decisions and saving lives. This is part 2 in a three course series on this topic.

Learning objectives:

  1. Describe clinical presentations of CNS Lyme Disease
  2. Describe ways to initialize differential diagnosis and diagnostic tools
  3. State three peer-reviewed references supporting treatment of  CNS Lyme Disease

CME Credit Pending. Application for CME credit has been filed with the American Academy of Family Physicians. Determination of credit is pending.

Evidence-based bibliography for further study

Belman AL, Iyer M, Coyle PK, Dattwyler R. Neurologic manifestations in children with North American Lyme disease. Neurology. 1993 Dec;43(12):2609-14. doi: 10.1212/wnl.43.12.2609. PMID: 8255465.

Clin Nucl Med. 2012 Sep;37(9):e219-22. doi: 10.1097/RLU.0b013e318262ad9b.
SPECT brain imaging in chronic Lyme disease.Donta ST, Noto RB, Vento JA.

Persistence of Borrelia burgdorferi in Rhesus Macaques following Antibiotic Treatment of Disseminated Infection Embers ME, Barthold SW, Borda JT, Bowers L, Doyle L, et al. (2012) Persistence of Borrelia burgdorferi in Rhesus Macaques following Antibiotic Treatment of Disseminated Infection. PLOS ONE 7(1): e29914.

Barthold SW, Hodzic E, Imai DM, Feng S, Yang X, Luft BJ. Ineffectiveness of tigecycline against persistent Borrelia burgdorferi. Antimicrob Agents Chemother. 2010 Feb;54(2):643-51. doi: 10.1128/AAC.00788-09. Epub 2009 Dec 7. PMID: 19995919; PMCID: PMC2812145.

Resurgence of Persisting Non-Cultivable Borrelia burgdorferi following Antibiotic Treatment in Mice Hodzic E, Imai D, Feng S, Barthold SW (2014) Resurgence of Persisting Non-Cultivable Borrelia burgdorferi following Antibiotic Treatment in Mice. PLOS ONE 9(1): e86907.

Adriana Marques, Sam R. Telford, III, Siu-Ping Turk, Erin Chung, Carla Williams, Kenneth Dardick, Peter J. Krause, Christina Brandeburg, Christopher D. Crowder, Heather E. Carolan, Mark W. Eshoo, Pamela A. Shaw, Linden T. Hu, Xenodiagnosis to Detect Borrelia burgdorferi Infection: A First-in-Human Study, Clinical Infectious Diseases, Volume 58, Issue 7, 1 April 2014, Pages 937–945,

Jowett N, Gaudin RA, Banks CA, Hadlock TA. Steroid use in Lyme disease-associated facial palsy is associated with worse long-term outcomes. Laryngoscope. 2017 Jun;127(6):1451-1458. doi: 10.1002/lary.26273. Epub 2016 Sep 6. PMID: 27598389

Nucl Med Commun. 2002 Aug;23(8):773-7.Cerebral metabolic changes associated with Lyme disease.Newberg A1, Hassan A, Alavi A.

Hildenbrand P, Craven DE, Jones R, Nemeskal P. Lyme neuroborreliosis: manifestations of a rapidly emerging zoonosis. AJNR Am J Neuroradiol. 2009 Jun;30(6):1079-87. doi: 10.3174/ajnr.A1579. Epub 2009 Apr 3. PMID: 19346313; PMCID: PMC7051319.

Lindland ES, Solheim AM, Andreassen S, Quist-Paulsen E, Eikeland R, Ljøstad U, Mygland Å, Elsais A, Nygaard GO, Lorentzen ÅR, Harbo HF, Beyer MK. Imaging in Lyme neuroborreliosis. Insights Imaging. 2018 Oct;9(5):833-844. doi: 10.1007/s13244-018-0646-x. Epub 2018 Sep 4. PMID: 30187265; PMCID: PMC6206375.

Garkowski A, Zajkowska J, Zajkowska A, Kułakowska A, Zajkowska O, Kubas B, Jurgilewicz D, Hładuński M, Łebkowska U. Cerebrovascular Manifestations of Lyme Neuroborreliosis-A Systematic Review of Published Cases. Front Neurol. 2017 Apr 20;8:146. doi: 10.3389/fneur.2017.00146. PMID: 28473801; PMCID: PMC5397664.

Wittwer B, Pelletier S, Ducrocq X, Maillard L, Mione G, Richard S. Cerebrovascular Events in Lyme Neuroborreliosis. J Stroke Cerebrovasc Dis. 2015 Jul;24(7):1671-8. doi: 10.1016/j.jstrokecerebrovasdis.2015.03.056. Epub 2015 May 20. PMID: 26002071.

Qual Life Res. 2013 Feb;22(1):75-84.Post-treatment Lyme disease syndrome symptomatology and the impact on life functioning: is there something here?Aucott JN1, Rebman AW, Crowder LA, Kortte KB.

Eric L. Logigian, Richard F. Kaplan, Allen C. Steere, Successful Treatment of Lyme Encephalopathy with Intravenous Ceftriaxone, The Journal of Infectious Diseases, Volume 180, Issue 2, August 1999, Pages 377–383,

About Instructor

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Course Includes

  • 1 Lesson
  • 2 Quizzes
  • Course Certificate