7 years of blood-based Lyme disease testing

Credit pending approval. This presentation discusses demographic changes in Lyme disease, including rising case numbers in traditionally low incidence states.

Elizabeth Lee-Lewandrowski, PhD, MPH
Massachusetts General Hospital
Harvard Medical School

Many clinicians based diagnostic decisions on their assessment as to the likelihood that a patient has Lyme disease. Most consider epidemiologic data that is derived from surveillance case reports. However, this may underestimate risk for patients that reside in what has been considered traditionally low incidence states. This presentation documents the changing geographic demographics of the illness and clinicians in some areas of the country may need to reconsider how they assess a patient’s risk of Lyme disease.

Learning objectives:

  1. Participants will be able to describe the relative frequency of Lyme disease (LD) cases reported to the CDC across different regions of the United States
  2. Participants will be able to describe the CDC criteria for the laboratory case definition of LD and the limitations of currently available testing
  3. Participants will be able to describe trends in the frequency of LD cases over time and the changing national epidemiologic demographics of LD across different regions

Application for CME credit has been filed with the American Academy of Family Physicians. Determination of credit is pending.

Evidence-based bibliography for further study



• Hinckley A, Neeta C, Meek J, Johnson B. Kemperman M, Feldman K, White J, Mead P. Lyme disease testing by large commercial laboratories in the United States. Clin Infec Disease  2014;59:676-681

• Rudolf J, Baron J, Branda J, Lee-Lewandrowski E. Laboratory testing for tick-borne infections in a large Northeastern academic medical center: a ten-year experience. Amer J Clin Pathol 2018;150:415-420

• Lee-Lewandrowski E, Chen Z, Branda J, Baron J, Kaufman H. Laboratory blood-based testing for Lyme Disease at a national reference laboratory. Amer J Clin Pathol 2019;152:91-96

Not Enrolled

Course Includes

  • 1 Lesson
  • 2 Quizzes
  • Course Certificate